Next-Generation Regenerative Orthopedics

By bringing the comprehensive, cellular medicine approach we employ in our other service offerings to the typically slow-to-change field of orthopedics, we offer regenerative orthopedic consults and procedures aimed at helping you heal and strengthen in the long term (not just alleviating immediate pain).

BLI’s Regenerative Orthopedic Services

Platelet Rich Plasma (PRP) / Platelet Rich Fibrin Matrix (PRFM)

PRP/PRFM are injections of a concentration of a patient’s own platelets to assist with the healing of injured tendons, ligaments, muscles, and joints.

AOD 9604 + HA

AOD9604 is a GH fragment which comprises the last 16 amino acids of the larger growth hormone molecule.

Alpha-2-Macroglobulin (A2M)

Alpha-2-Macroglobulin, more commonly referred to as A2M, is a master protease inhibitor that already exists in your blood and acts as a powerful inhibitor of cartilage breakdown.

Pentosan Polysulfate

Australian researcher and physician, Dr. Peter Ghosh from the University of Sydney has brought an old drug back into the light for arthritis sufferers.

Orthopedic Consultations

Orthopedic Planning Consult

During this 30 minute appointment, you can discuss your challenges, concerns, and questions with the provider and gain guidance and recommendations on next steps or alternate approaches.

Only available to first time orthopedic clients

Orthopedic Imaging Review

30 minute appointment to review imaging related to your orthopedic issue or concern and get expert feedback and advice.

Only available to new clients or as follow-up to Planning Consult

Orthopedic General Consult

Opportunity to continue receiving expert guidance and care regarding your orthopedic concerns.

For returning clients/ongoing follow-ups


"Is regenerative medicine legitimate?"

The progression of modern medicine has created a bit of skepticism in things that sound new or futuristic. This skepticism leads many to wonder if regenerative medicine is even legitimate.

As functional medicine, which professed a “root cause” mentality, intertwined with holistic, naturopathic, and alternative medicines, a hesitancy developed about what seemed like a confused approach to looking at the issues with the systems causing symptoms.

Specializing in what it calls, “better medicine,” the Boulder Longevity Institute aims to eliminate the confusion by focusing on cutting edge, science-backed treatment options in a clinical environment.

A secondary challenge with regenerative medicine, making it seem less accessible, is the more detailed science and data driven nature of the field. While the data is proving invaluable as we get better at Cellular Medicine (the approach to healthcare that involves looking at the cellular pathways and behaviors that cross over multiple systems), it can feel overwhelming if not approached from a human first perspective.

The Boulder Longevity Institute aims to offer clients a legitimate, guidance based practice that leverages the most advanced knowledge while balancing the needs of each individual. By offering clients the latest science and research applied in a clinical setting, BLI weaves regenerative, cellular, and functional medicine into a comprehensive approach to optimizing health.

"How does pentosan work?"

Pentosan, also known as sodium pentosan polysulfate (PPS) has been used in humans for over six decades. Pentosan works as an anti-inflammatory and inhibits cartilage enzymatic breakdown.

Hitting the market as Elmiron, pentosan has been used as a treatment for the inflammatory ailment of the bladder called interstitial cystitis.

More recently, pentosan is being injected into patients suffering from knee osteoarthritis (OA) and the symptoms from the common lesions associated with OA. These patients are seeing pain relief and in some cases, cartilage regeneration.

Pentosan is not administered into the joint space, like most common treatments for knee OA. This has led researchers to investigate how Pentosan might shine light on osteoarthritis being a disease caused by systemic issues, versus the common approach believing OA is strictly related to knee trauma or wear and tear.

While Pentosan is showing great promise as a game changer in cartilage loss associated with OA, it is considered “off-label” for the purposes of osteoarthritis treatment. However, the United States FDA has fast-tracked the use of PPS (under the brand name Zilosul) for OA.

Clinical trials are ongoing but the chances of Pentosan becoming a treatment for OA look promising.

"What Is a Platelet-Rich Plasma (PRP) Injection?"

Platelet-rich plasma (PRP) is the liquid portion of blood (plasma) and platelets (a type of blood cell that helps with healing). A PRP injection is simply blood with more platelets than usual injected into the body. Platelet-rich Fibrin Matrix (PRFM) is similar to PRP, but often thought of as the next generation of PRP treatments. Similar to PRP treatments, PRFM uses injections of a concentration of a patient’s own platelets to assist with the healing of injured tendons, ligaments, muscles, and joints.

Most of us have heard of platelets because of their role in blood clotting. There is a therapeutic role for platelets to play, as well. Platelets contain growth factors that have various benefits including angiogenesis, encourage regeneration, and stimulate healing in an area of injury.

A PRP injection is actually a reinjection of your own blood! A sample is drawn and spun in a device called a centrifuge. The spinning causes the platelets to separate from the other components in the blood sample, gathering in the plasma.

Now that the PRP has been created, it can be loaded as an injection to be used therapeutically. Ideally, the injection is placed as closely to the injury site as possible. Many providers use ultrasound guidance to ensure the injection goes exactly where they determine it would be most useful.

Research shows that the buildup of growth factors found in the PRP could stimulate and expedite healing, leading to a faster recovery time overall. Furthermore, PRFM has been shown to be even more efficacious than PRP for joint repair.


“How long do PRP injections last?”

The length of the impact of a PRP injection is a little subjective but depending on the injury, there could be six to nine months of effect.

It is important to note that a PRP injection can provide pain relief but will ideally be combined with other therapies that will aid in recovery from the injury or chronic problem.


“Do PRP injections hurt?”

Many people say a PRP injection is about as painful as any other injection. Of course, every individual tolerates pain differently.

There is also some notable difference in pain level based on the location and extent of the injection. This is based on the site of the injury or chronic ailment.


“What is the success rate of PRP injections?”

There is no consensus on a firm success rate of PRP injections. Studies have shown a reduction in pain in a large portion of participants.

PRP injections are not typically considered a stand-alone treatment for pain. Ideally, PRP is used to improve your ability to heal while addressing rehabilitation from injury or inflammation causing chronic problems.


“How long does it take for PRP to start working?”

The PRP injection begins working immediately by concentrating platelets in the area of an injury or chronic damage. This allows the healing process to commence.

The noticeable results of pain relief typically hit their peak in the three to six week range. Importantly, PRP injections can continue to aid the healing process for up to nine months after the procedure.


“Is PRP a permanent solution?”

The results of a PRP injection are not permanent. Ideally, during the six to nine month timeframe that a PRP injection is effective, the body would be able to heal from whatever injury or chronic ailment. The goal of regenerative therapies like PRP is to not just be a band-aid but actually to restore tissue so the hope is results are long lasting!

There are cases where second PRP injections could be determined to be helpful. This would be at the discretion of your provider based on your circumstances.

Ready to feel better than ever?

We provide foundational health with a cellular lens for health-motivated individuals who seek to optimize their well-being.

QuickCourse: Treating Joint & Back Pain - Dr. Elizabeth Yurth provides the latest science on what's causing your joint & back pain and how to treat (not simply patch, replace, or fuse) it in three easy-to-follow modules! Start online today on the Human Optimization Academy!