In this episode, Kayla Barnes-Lentz sits down with Dr. Elizabeth Yurth, co-founder of Boulder Longevity Institute and a physician with more than 30 years of experience in orthopedic and sports medicine, to take a deeper look at women’s joint, bone, hormonal, and mitochondrial health.
After decades of treating injuries and “patching people back together,” Dr. Yurth explains why she believes we need to rethink the way we approach osteoarthritis, bone loss, and musculoskeletal health, particularly in women. They explore how hormonal changes, mitochondrial dysfunction, chronic inflammation, and declining muscle mass can all contribute to the conditions women are often told are simply a normal part of aging.
The conversation goes far beyond traditional orthopedic care, covering progesterone and estrogen, perimenopause, birth control, bone density and DEXA scans, strength training, mitochondrial repair, peptides, regenerative therapies, and the importance of optimizing the body before attempting to regenerate damaged tissue.
Dr. Yurth and Kayla also discuss why prevention needs to begin long before a joint, tendon, or bone “breaks,” how women can take a more proactive approach to musculoskeletal longevity, and why regenerative medicine may offer tools that conventional medicine has historically overlooked.
🤓 What you’ll learn:
➡️ Why osteoarthritis may be more than a simple “wear and tear” condition and how metabolic health can influence joint degeneration
➡️ The important role hormones – particularly progesterone – play in protecting bones, tendons, ligaments, and joints
➡️ Why women may be particularly vulnerable to ACL injuries, bone loss, and musculoskeletal changes throughout midlife
➡️ When women should consider getting a DEXA scan and why bone health needs to be addressed before a fracture occurs
➡️ How strength training, muscle contraction, Zone 2, and BFR can support long-term health and longevity
➡️ Why mitochondrial dysfunction may contribute to problems across multiple systems, including muscle, joints, and the brain
➡️ The importance of repairing dysfunctional mitochondria before attempting to increase their activity
➡️ How peptides and other regenerative therapies are being explored for tissue repair, recovery, and healthy aging
➡️ Why optimization of the body’s underlying environment is critical before pursuing regenerative treatments
➡️ The differences between therapies such as PRP and A2M and where they may fit into regenerative medicine
➡️ Why inflammation can affect both joint health and broader cardiovascular health
➡️ How women can begin thinking about musculoskeletal health as a lifelong longevity strategy – not something to address after an injury occurs
This episode is for you if:
– You’re a woman interested in protecting your joints, bones, muscles, and mobility as you age
– You’re navigating perimenopause or midlife and want to better understand the connection between hormones, mitochondria, and musculoskeletal health
– You’re interested in peptides, regenerative medicine, and proactive approaches to preventing and addressing age-related decline
In this episode of The Longevity Optimization Podcast, Dr. Yurth and Kayla Barnes-Lentz discuss…
✅ Women’s joint & bone health: Why osteoarthritis, ligament injuries, and bone loss should be viewed through the lens of hormones, metabolism, inflammation, and mitochondrial health—not simply aging or “wear and tear.”
✅ Mitochondria, hormones & longevity: How mitochondrial dysfunction, hormonal decline, muscle loss, and inflammation intersect—and why repairing the underlying biology is essential to long-term health.
✅ The future of regenerative medicine: How peptides, regenerative therapies, strength training, and proactive optimization can help shift women’s healthcare from treating injuries after they happen to preserving function, mobility, and healthspan before problems begin.
🎧 Click below to tune in to The Longevity Optimization Podcast with Kayla Barnes-Lentz: Why Joint and Muscle Start To Decline in Your 20s | Dr. Elizabeth Yurth, MD
Interested in learning more about how you can improve your health & longevity with cellular medicine? Get started here with Boulder Longevity Institute.
